A couple of years ago, after experiencing chases in OK several times, I came up with some hard and fast rules that really curtailed the amount of chasing I do. I first excluded anything east of I-35 (due to road network/trees/hills starting to become an issue), and then any metro area from chasing (other than local storm spotting), especially the OKC area, then expanding to OK north of OKC, and now pretty much all of OK, except far SW corner and the panhandle. With OKC, some of the factors involved you have already discussed; I feel trapped by my lack of road options (especially the ability to leave a road when necessary). Others include a huge amount of unequipped, unknowledgeable, and/or reckless individuals in that specific area that will go out and look at storms because the guys on the Discovery Channel do it or are jaded about storm activity simply from living there. I saw more and more of these folks on every chase, pointed in the right direction only by following other or by the excellent coverage from the local TV mets. Its not only bad in OKC, it gets really bad NW of there, especially on Hwy 412 from Woodward all the way to I-35. I desk chased the El Reno storm, just like every other storm in that area the last few years. I have been tempted several times to break that rule, but coverage on the OKC stations always makes me glad I dont.
My chasing terrain now consists of Texas west of I-35, SW OK (Lawton, Altus and thereabouts), CO, KS and north. I avoid the rest of OK like the plague. I always pick a target to the west of where I believe initiation to be, stay in the SW quadrant, and never come closer than a mile away.