For once my work schedule and a significant severe weather day appear to be working hand-in-hand (I have Thursday off). European models and the NAM have been fairly consistent in a very strong dynamic setup for Thursday which, depending on the yet-to-be-seen details, could stretch from S. MN to S.C. KS. Moisture will not be a problem this time of year. Oklahoma is sitting in the low 70 dewpoints consistently. With such a strongly forced setup there will be no problem advecting this rich gulf moisture northward by Thursday morning. I believe overnight convection (Wednesday into Thursday) will play a significant role in narrowing down the chase target but if I lived anywhere from the Twin Cities southwest to Wichita and eastward towards St. Louis, Chicago, Milwaukee, etc I would be keeping an eye on this system. Due to the strong dynamic forcing, shear will likely be approaching insane levels. Initiation will obviously not be an issue. At this point I'm waiting until Thursday morning to see how bad overnight convection screws things up as we are probably not going to need the added 0-1km SRH from OFB's. I'm thinking mid 60 dwpts to the MN/IA border, 70 degree dwpts in Des Moines and south to northern Missouri. South of there the boundary layer may mix out somewhat (sorry it's June.)
Just for kicks, the Davenport IA sounding looks primed for tornadic supercells, albeit moving very fast. These storms may be moving off to the NE-ENE approaching 60 mph. Right-movers may get somewhat of an ESE component which would increase the SRH even further (increasing shear at all levels given progged wind fields.)