The speed max near 750mb is a very interesting and unforecast development... As Kiel noted, the Fairbury NE profiler showed ~75kts at 750mb several hours ago; the Slater IA profiler is now up to 65kts near 750mb. The RUC analyses (both on the SPC Mesoscale and in 1hr forecast soundings) are only indicating ~50kts, so I think the 0-3km shear values/parameters may be stronger than the RUC is indicating. Regardless, with CAPE running >3000 j/kg, and >150 0-1km SRH west of DSM, I think there exists a threat for a strong tornado this afternoon IF a discrete supercell can develop. Surface flow remains relatively backed to the west of Des Moines, along the OFB boundary from earlier convection. CINH is currently proving to be too strong for initiation, but we'll see what happens in the coming 2-3 hours. Temps in extreme sw IA have warmed well into the 90s and strong mixing continues (partially encouraged by southwesterly flow not too far off the surface), resulting in veering sfc winds and dewpoints dropping below 60F. My virtual "want-to-be" location is somewhere along or just north of I80 between Avoca IA and Denison, where temps have been able to warm into the upper-80s and dewoints remain in the 70-73F range. Looking at the latest surface winds, it looks like there is some pretty good convergence occuring along that OFB, with 94/59 with SW winds near Omaha, and 88/70 with SSE winds just a little east of there. Temps are a little cool north of Denison for me to get too excited about intiation there (temps largely in the 79-82F range, versus the upper-80s closer to I80).
The areas farther north, nearer the IA/MN border, is slowly destabilizing, but it may be a too-little too-late deal up there. Lapse rates on the 18z MPX sounding were horrible (nearly moist-adiabatic), though that's largely because that area was worked over earlier. Again, initiation is going to be the concern IMO, but I think the best probs are just north of I80 in western IA.
EDIT: OAX 88D appears to show the western edge of the OFB, with some interesting smaller-scale features / kinks in the boundary near I70. 500mb winds on the Slater profiler leave a lot to be desired (~20kts), but higher midlevel winds are located to the west of DSM. In an unrelated area, it's 105F in Guymon OK and Dodge City KS right now... That's toasty.
EDIT2: The boundary is progressing northward rather quickly, so I'm aiming more towards Denison than I80 now... The OAX 88D shows some nice boundary layer rolls (reflectivity in the -5dbz to 10dbz range -- if you use GRx, make sure to set your colortable such that you can see <10dbz reflectivities) intersecting the OFB very near I80 northeast of Omaha right now.