Excellent choice, Mike!
Random automotive factoid here - what you have there is actually the last of the second generation 1995-1998 Pathfinder body style - it carried over into '99 until a redesigned body came out halfway through the model year, so you have the earlier of the two '99 body styles. And yes, I'm a total car geek. Could you tell? Lol.
Nissan Pathfinder's are among the most bulletproof vehicles you can buy on the market today. If you treat it right and keep up on maintenance, you'll get at least 200k out of that 3.3 liter V6 and 300k out of the powertrain and body.
The two things you will definitely miss going from the Escape to the Pathfinder is the the comfort level of the ride and, most of all, the fuel economy. The Escape's a car based, unibody frame where the Pathfinder is an old school, truck based body-on-frame, so you're going to feel the bumps, rough pavement and occasional trees, two by fours and telephone poles
a lot more harshly than you did in the Escape. The difference in fuel economy is definitely where you'll really feel a harsh jolt, at least to the old wallet, per say. Where your Escape was pulling off over 30 mpg highway, get ready for fuel economy numbers similar in nature to those you used to get with your 300C. I.e. 19mpg on the highway. Of course, the Escape only has high range AWD with non-lockable hubs, and the Pathfinder has a low range transfer case with lockable hubs, which makes the trade-off in fuel economy much more palatable.
Particularly when you find yourself on a greasy dirt road after a heavy rainstorm...
One recommendation I have is that you purchase a cold air intake for your Pathfinder. The 3.3 V6 is slightly underpowered at 168 horsepower, which can get quite doggy hauling around the Pathfinders 3960 pounds. A friend of mine used to have a '96 Pathfinder 4WD, and after he installed the cold air intake, it had significantly more power and he went from 16 mpg combined to almost 18 mpg combined and up to 20 mpg on long road trips, so for around $200, it would be a worthwhile investment that would pay for itself fairly quickly.
Once more, congrats on your new ride! I know you'll enjoy it...