It depends. If you're scheduling time off in advance, meaning it's before seeing a storm in the short/medium-range forecasts, it's really not worth it. Their season can be all over the place, meaning it's not very consistent. In May in the Plains, you're usually pretty well off, especially during the latter part of the month. In April, Dixie can light up, but it's also not uncommon for a
lot of down time. If you see a sequence or outbreak coming up, then that's a different story.
As
@Dan Robinson said, storms are generally more HP/less classic here. Western parts of Dixie, from southern Missouri into Arkansas and northeastern Texas can see some dryline events and/or more LPish storms, but as I'll mention below, this area is around the Ozarks and that is some intensely challenging chase territory.
So, even if you have storms, it depends where you go. Areas just on either side of the Mississippi River are not bad for chasing (terrain and road network), including much of eastern Arkansas, northwestern Mississippi and southeastern Missouri. The trouble here is that your window of opportunity is rarely narrow. Most of Dixie is really awful when it comes to trees and poor road networks, outside of the areas mentioned and a few other spots in southwestern and northeastern Louisiana.
Anywhere near the Ozarks is among the worst chase terrain between the Rockies and Appalachians.
With that said, I have had some decent success in Dixie, from mid-March through late April. Most years in Dixie tend to have a higher end (or two) event during the last week of April. It doesn't always happen, but it seems like most years have a vigorous trough swinging through with a good CAPE/shear combination. This is the transition period, as Dixie tornado events (not counting tropical systems) become uncommon after the first week of May, but there is usually substantial instability with any storm system with strong wind profiles that moves into the Mid-South around this time.
If you have flexibility and see a high-end event coming up, long-track tornadoes are as common in Dixie (northern Louisiana into Mississippi/Alabama) as they are in the central Plains. The trade off is that you have more trees, hills and populated areas to factor in, so it's rarely easy to chase there.
Would I ever advise someone take a chasecation in Dixie? No.
Is it worth chasing in Dixie? For a one-off chase or a significant event, it can pay off, but just keep in mind that the obstacles in Dixie mean that you'll have limited visibility, less room for error and generally less photogenic storms than you would expect to see in the Plains.
One of my favorite Dixie chase stories is seeing two significant tornadoes in two different states on the same day, which was one day before my birthday, on February 2nd, 2016. I rarely chase in the winter, but that chase across Mississippi and Alabama was quite memorable.